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. Author manuscript; available in PMC: 2019 Jul 6.
Published in final edited form as: Org Lett. 2018 Jun 11;20(13):3853–3857. doi: 10.1021/acs.orglett.8b01440

Table 2.

Reaction Substrate Scope.a

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a

Reaction conditions: 1a (0.1 mmol), 2a (1.5 equiv), Pd(OAc)2 (10 mol %), DMBQ (2 equiv), K2CO3 (1 equiv), HFIP (0.2 mL), 100 °C, O2 (1 atm), 12–16 h. Percentages refer to isolated yields.

b

Intramolecular cyclized compound was also recovered (see footnote 13).

c

Pd(OAc)2 (15 mol%), 120 °C, 2 d.

d

N-(but-3-en-1-yl)picolinamide was used as the alkene.