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. Author manuscript; available in PMC: 2019 Jul 15.
Published in final edited form as: J Immunol. 2018 May 21;201(2):652–662. doi: 10.4049/jimmunol.1800210

FIGURE 4.

FIGURE 4

Effect of PEPT2 on the expression of IL-6 and TNF-α in BMDMs of wildtype and Pept2 knockout mice. BMDMs were treated for 24 hr with 0–10 ng/mL LPS plus 10 μg/mL MDP (L,D-isomer; A and B), tri-DAP (C and D), or 10 ng/mL LPS plus 10 μg/mL MDP control (L,L-isomer; E and F), after which cytokine concentrations in the cell culture media were measured. Data are expressed as mean ± SE (n=4) in which each experiment was performed in triplicate. Statistical differences between the two genotypes were determined by an unpaired (two-sample) t-test. *p ≤ 0.05, **p ≤ 0.01 and ***p ≤ 0.001.