Fig. 3.

Topography of the outer retinal changes after MEK/BRAF inhibition. Shown are 30° × 25° topography maps of the distance (or thickness) between the internal limiting membrane and the RPE/BrM layer defined by SD-OCT in 8 of the patients at their baseline (BSL) visits compared with a visit (V1) ~30 days after initiation of the clinical trial medications. Only the right eye shown for clarity. Thickness values (in µm) are mapped to a color scale (bottom right). Superimposed is an early treatment diabetic retinopathy study grid centered at the foveola. Concentric circles of increasing radii divide the central macula in subfields: Central (500 µm radius), inner parafoveal (1,500 µm), and outer perifoveal (3,000 µm).