Table 1.
Baseline characteristics of the participants overall and by sex.
| Progression to probable AD | Progression to MCI | |||||
|---|---|---|---|---|---|---|
|
|
|
|||||
| Variables | Women | Men |
P value of t or X2 |
Women | Men |
P value of t test or X2 |
| Age | 77.75 | 76.76 | .39 | 70.44 | 72.98 | .02 |
| Std deviation of age | [9.44] | [7.12] | [11.77] | [10.31] | ||
| Education: 0–12 yrs | 38.68% | 29.52% | .16 | 23.73% | 25.15% | .73 |
| Education: 12–16 yrs | 48.11% | 38.10% | .14 | 47.15% | 35.33% | .01 |
| Education: ≥17 yrs | 13.21% | 32.38% | .00 | 29.11% | 39.52% | .02 |
| Race: White | 55.66% | 73.33% | .01 | 69.94% | 76.05% | .16 |
| Race: Black/African American | 22.64% | 14.29% | .12 | 16.77% | 8.98% | .02 |
| Hispanic | 17.92% | 10.48% | .12 | 11.71% | 11.98% | .93 |
| Other racial group | 3.77% | 1.90% | .41 | 1.58% | 2.99% | .30 |
| No APOE ε4 | 59.43% | 56.19% | .63 | 66.46% | 61.68% | .30 |
| 1 APOE ε4 allele | 33.96% | 35.24% | .85 | 29.43% | 35.93% | .14 |
| 2 APOE ε4 alleles | 6.60% | 8.57% | .59 | 4.11% | 2.40% | .33 |
| CDRGLOB = 0 | 13.21% | 14.29% | .82 | 87.97% | 77.25% | .00 |
| CDRGLOB = 0.5 | 82.08% | 80.95% | .83 | 12.03% | 22.75% | .00 |
| CDRGLOB = 1 | 4.72% | 4.76% | .99 | 0.00% | 0.00% | NA |
| Delusion | 3.13% | 5.88% | .35 | 0.00% | 1.20% | .05 |
| Hallucination | 1.04% | 0.98% | .97 | 0.32% | 0.00% | .47 |
| Agitation | 14.58% | 17.65% | .56 | 6.01% | 8.98% | .23 |
| Depression | 34.38% | 29.41% | .45 | 14.56% | 20.96% | .07 |
| Anxiety | 16.67% | 20.59% | .48 | 9.49% | 12.57% | .30 |
| Elation | 2.08% | 3.92% | .45 | 0.32% | 0.60% | .65 |
| Apathy | 16.67% | 17.65% | .86 | 3.48% | 7.19% | .07 |
| Disinhibition | 8.33% | 11.76% | .42 | 4.43% | 4.19% | .90 |
| Irritability | 26.04% | 35.29% | .16 | 9.49% | 19.16% | .00 |
| Motor disturbance | 2.08% | 3.92% | .45 | 1.58% | 0.60% | .35 |
| Nighttime behavior | 15.63% | 22.55% | .22 | 10.76% | 15.57% | .13 |
| Appetite disturbance | 11.46% | 10.78% | .88 | 5.38% | 5.99% | .78 |
| Hypertension | 74.53% | 73.33% | .84 | 52.85% | 56.29% | .47 |
| Hypercholesterolemia | 66.04% | 67.62% | .81 | 53.80% | 59.28% | .25 |
| Diabetes | 16.98% | 30.77% | .02 | 19.94% | 21.56% | .68 |
| Hippocampal volume | 0.60% | 0.57% | .00 | 0.64% | 0.61% | .00 |
| Std deviation | [0.00] | [0.00] | [0.00] | [0.00] | ||
| White matter hyperintensities | 1.10% | 1.00% | .64 | 0.66% | 0.58% | .44 |
| Std deviation | [0.01] | [0.02] | [0.01] | [0.01] | ||
| Number of participants | 106 | 105 | 316 | 167 | ||
| Number of follow-up days | 1108.76 | 1021.10 | .39 | 1268.46 | 1170.3 | .22 |
| Std deviation | [786.45] | [702.00] | [885.21] | [780.99] | ||