Table 2.

Cox regression analyses examining the hazard of progression to Alzheimer’s disease or mild cognitive impairment given hippocampal volume or white matter hyperintensities.

	Progression to AD				Progression to MCI
	Hippocampal volume		WMH		Hippocampal volume		WMH
	Women	Men	Women	Men	Women	Men	Women	Men
Hippocampal volume	0.535** (0.300–0.953)	0.548 (0.297–1.011)			0.386** (0.166–0.901)	0.975 (0.389–2.445)
White matter hyperintensities			0.991 (0.956–1.028)	1.018 (0.996–1.040)			1.010 (0.984–1.037)	1.048** (1.011–1.086)
White	1.085 (0.467–2.521)	4.396** (1.012–19.08)	1.454 (0.656–3.223)	4.665** (1.072–20.29)
Age					1.092*** (1.035–1.151)	1.101*** (1.037–1.169)	1.084*** (1.028–1.143)	1.075** (1.008–1.146)
CDRGLOB = 0.5	3.954 (0.526–29.71)	0.679 (0.222–2.076)	4.552 (0.613–33.81)	0.807 (0.250–2.609)	1.808 (0.605–5.406)	1.165 (0.392–3.459)	1.533 (0.525–4.478)	1.110 (0.377–3.266)
CDRGLOB = 1	5.260 (0.465–59.52)		7.562 (0.639–89.48)
Disinhibition					3.014 (0.527–17.25)	1.796 (0.360–8.967)	1.979 (0.352–11.12)	1.987 (0.394–10.03)
Irritability					1.486 (0.314–7.028)	2.865 (0.985–8.331)	1.570 (0.324–7.610)	2.779 (0.934–8.266)
Nighttime behavior					1.832 (0.587–5.719)	1.044 (0.263–4.135)	2.048 (0.656–6.396)	1.154 (0.312–4.263)
Appetite disturbance					1.127 (0.236–5.369)	1.565 (0.280–8.745)	1.425 (0.290–6.986)	1.341 (0.233–7.721)
Observations	106	105	106	105	316	167	316	167

95% CI in parentheses.

^***P < .01,

^**P < .05.