Table 3.

Generalized linear mixed model analyses examining the odds of Alzheimer’s disease or mild cognitive impairment given hippocampal volume or white matter hyperintensities.

	Probable AD				MCI
	Hippocampal volume		WMH		Hippocampal volume		WMH
	Women	Men	Women	Men	Women	Men	Women	Men
Hippocampal volume	0.403 (0.231–0.701)***	0.468 (0.263–0.832)***			<0.01*** (0–0.026)	0.22 (0–3081.895)
White matter hyperintensities			0.984 (0.943–1.028)	1.009 (0.981 –1.039)			0.931 (0.678–1.278)	1.541 (0.992–2.395)
Time (per 30 days)	1.027*** (1.013–1.041)	1.032*** (1.017–1.047)	1.024*** (1.011 –1.037)	1.033*** (1.018–1.048)	1.027*** (1.014–1.04)	1.045*** (1.03–1.059)	1.025*** (1.012–1.038)	1.046*** (1.031 –1.061)
White	1.166 (0.503–2.707)	5.297** (1.485–18.893)	1.417 (0.596–3.368)	5.278*** (1.462–19.054)
CDRGLOB = 0.5	4.475 (0.824–24.291)	1.028 (0.277–3.813)	5.294 (0.903–31.05)	0.841 (0.233–3.03)	4.442*** (1.62–12.174)	1.729 (0.464–6.447)	3.581** (1.306–9.821)	1.741 (0.465–6.519)
CDRGLOB = 1	5.306 (0.528–53.341)		10.634 (0.905–124.986)
Age					1.096*** (1.042–1.152)	1.051 (0.986–1.121)	1.086*** (1.032–1.142)	1.029 (0.962–1.1)
Disinhibition					6.01** (1.052–34.322)	1.423 (0.14–14.41)	3.126 (0.555–17.593)	1.563 (0.157–15.588)
Irritability					1.408 (0.346–5.733)	3.117 (0.817–11.894)	1.566 (0.381 –6.43)	3.015 (0.779–11.66)
Nighttime behaviour					1.708 (0.507–5.757)	0.53 (0.104–2.689)	1.929 (0.556–6.693)	0.586 (0.122–2.804)
Appetite					0.425 (0.073–2.463)	0.939 (0.107–8.236)	0.655 (0.116–3.691)	0.664 (0.068–6.446)

95% CI in parentheses.

^***P < .01,

^**P < .05.