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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Eur J Pharm Sci. 2018 Jan 10;126:3–10. doi: 10.1016/j.ejps.2018.01.020

Figure 1.

Figure 1

(A) Manufacture of uniform drug loaded microspheres begins by dispersing drug in a solution of controlled release polymer and organic solvent. A uniform emulsion is made with acoustic excitation, after which the organic phase is extracted and microspheres lyophilized. Dried microsphere powders are then ready for resuspension in applicable film forming agent and transtympanic injection. (B) Once microspheres are suspended in an FFA component, they can be deposited on the round window membrane. Reversal of the procedure could be accomplished with water, as the FFA components are water soluble.