Table 3.
Cox Regression Analysis, RFS (n = 573)⁎
| Parameter | Simple Analysis |
Multiple Analysis (CD3+ TILs) |
Multiple Analysis (CD8+ TILs) |
|||
|---|---|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | HR (95% CI) | P Value | |
| Age | ||||||
| <73 | 1 | <.001 | 1 | <.001 | 1 | <.001 |
| ≥73 | 1.854 (1.405-2.446) | 1.999 (1.499-2.668) | 2.006 (1.504-2.675) | |||
| Sex | ||||||
| Male | 1 | 0.440 | - | - | - | - |
| Female | 0.901 (0.692-1.174) | |||||
| T-category | ||||||
| T3 | 1 | .009 | 1 | .012 | 1 | .011 |
| T4 | 1.612 (1.128-2.305) | 1.602 (1.108-2.315) | 1.611 (1.115-2.328) | |||
| Malignancy grade | ||||||
| Medium/Low | 1 | .820 | - | - | - | - |
| High⁎ | 1.038 (0.754-1.429) | |||||
| Localization | ||||||
| Right | 1 | .094 | 1 | .159 | 1 | .187 |
| Left | 1.256 (0.962-1.639) | 1.251 (0.916-1.709) | 1.233 (0.903-1.685) | |||
| Tumor perforation | ||||||
| No | 1 | .010 | 1 | .014 | 1 | .016 |
| Yes | 2.301 (1.218-4.349) | 2.257 (1.178-4.325) | 2.230 (1.161-4.280) | |||
| Lymph nodes | ||||||
| <12 nodes | 1 | .453 | - | - | - | - |
| ≥12 nodes | 0.901 (0.685-1.184) | |||||
| Perineural invasion | ||||||
| No | 1 | .112 | - | - | - | - |
| Yes | 1.585 (0.898-2.799) | |||||
| Vascular invasion | ||||||
| No | 1 | .708 | - | - | - | - |
| Yes | 1.100 (0.667-1.816) | |||||
| Mismatch repair status | ||||||
| MSS | 1 | .057 | 1 | .455 | 1 | .400 |
| MSI | 0.746 (0.552-1.009) | 0.870 (0.603-1.255) | 0.855 (0.594-1.231) | |||
| CD3-invasive | ||||||
| High | 1 | .001 | 1 | .026 | - | - |
| Low | 1.549 (1.183-2.030) | 1.386 (1.039-1.850) | ||||
| CD8-invasive | ||||||
| High | 1 | .001 | - | - | 1 | .032 |
| Low | 1.621 (1.219-2.156) | 1.394 (1.029-1.890) | ||||
Invasive refers to the area of the outermost front of the adenocarcinoma, including the deepest invasive front of the tumor, areas with tumor budding, and/or irregular tumor islands.
⁎
Including mucinous adenocarcinomas and signet-ring cell carcinomas.