Table 1.

50% and 90% effective (ED) and lethal (LD) doses (mg/kg) for the liposomal amphotericin B (AmB) formulations AmBisome^® (A) and Fungisome^® (F) in the L. major-BALB/c model of CL, based on toxicity and Fig. 1 data. The number of lethal events per group over the full course of treatment was monitored during treatment for calculation of LD values. At day 10, parasite load (PL) and lesion size (LS) were determined and effect expressed as relative percentage of reduction compared to the untreated control group, which was used to calculate ED values. Therapeutic indices (TI) were calculated as the LD over ED ratio. As no lethal events occurred for A at the tested dose levels, reference LD values from mice (*) were used from the AmBisome^® FDA pharmacological review document, application number 050740 (Drug Approval Package).

	AMBISOME®		FUNGISOME®
	50%	90%	50%	90%
LD	133.0*	150.0*	12.3	16.9
EDPL	3.0	4.5	4.0	11.0
EDLS	8.8	51.3	12.8	102.8
TIPL	44.9	33.0	3.1	1.5
TILS	15.1	2.9	1.0	0.2