Table 2.
Comparative anti-plasmodial activity of selected compounds in 48 h versus 72 h growth inhibition assays and cytotoxicity activity against HEK 293 cells.
| Compounds |
PfDd2 IC50 (μM) |
p value | HEK 293 IC50 (μM) | SIa | |
|---|---|---|---|---|---|
| 48 h | 72 h | ||||
| SGC-CBP30 | 10.03 (±0.32) | 3.16 (±1.94) | 0.006 | 22.09 (±2.00) | 2–7 |
| OSSK_842646 | 11.28 (±2.00) | 6.35 (±2.45) | 0.073 | >50 | >4 |
| OSSL_258906 | 11.80 (±3.06) | 5.96 (±1.19) | 0.051 | >50 | >4 |
| CQ | 0.11 (±0.04) | 0.05 (±0.02) | 0.052 | 18.58 (±1.95) | 169–372 |
a
SI – Selectivity index (mammalian cell IC50/PfDd2 IC50).