Fig. 3.

ugt-22 is induced in skn-1(k1023gf) worms. (A) Venn diagram of genes induced at least 2-fold in microarray data of 1.13 mM albendazole and RNAseq of skn-1(k1023gf) (gf, gain-of-function) worms (Laing et al., 2010; Peddibhotla et al., 2015). (B) Relative mRNA levels of the five overlapping genes in skn-1(k1023gf) worms (**P<0.01; ***P<0.001 relative to wild type worms (N2), n = 3–4 replicates of worms). (C) Percent long-term spontaneous motility of adult skn-1(k1023gf) worms fed E. coli HT115 expressing control, cyp-35c1, gst-5, ugt-22, or ugt-63 dsRNA and exposed to 11 μM albendazole for 3 days (***P<0.001 relative to feeding with control dsRNA by Chi-square analysis, n = 60–187 worms).