Table 3.
Characteristics of subjects with WISP-1/CCN4 over and under detection limit
| WISP-1/CCN4 detectable | WISP-1/CCN4 not detectable | p-value | |
|---|---|---|---|
| Total N | 147 | 106 | |
| NGT/IFG + IGT/T2DM (N) | 29/108/10 | 22/76/8 | |
| Sex (% male) | 36.1 | 37.7 | |
| Age (years) | 58.8 ± 9.3 | 58.0 ± 10.0 | 0.527 |
| Weight (kg) | 88.4 ± 16.4 | 89.8 ± 16.8 | 0.513 |
| BMI (kg/m2) | 31.5 ± 5.0 | 31.8 ± 4.9 | 0.479 |
| Waist circumference (cm) | 102.3 ± 12.6 | 102.2 ± 12.1 | 0.937 |
| Hip circumference (cm) | 111.3 ± 11.3 | 111.8 ± 10.5 | 0.653 |
| Waist-to-hip ratio | 0.92 ± 0.08 | 0.92 ± 0.08 | 0.605 |
| HOMA-IR | 2.23 ± 1.21 | 2.21 ± 1.24 | 0.920 |
| HbA1c (%) | 5.44 ± 0.43 | 5.35 ± 0.44 | 0.098 |
| HDL (mmol/L) | 1.32 ± 0.29 | 1.23 ± 0.30 | 0.025 |
| LDL (mmol/L) | 3.60 ± 0.89 | 3.38 ± 0.78 | 0.041 |
| Triglycerides (mmol/L) | 1.44 ± 0.84 | 1.38 ± 0.75 | 0.606 |
| Total cholesterol (mmol/L) | 5.58 ± 1.09 | 5.23 ± 0.88 | 0.007 |
| ALT (U/L) | 26.4 ± 14.8 | 28.4 ± 22.4 | 0.513 |
| Body fat (%) | 37.8 ± 8.3 | 37.5 ± 8.1 | 0.765 |
| VAT (%) | 4.57 ± 1.96 | 4.68 ± 2.20 | 0.760 |
| IHL (%) | 8.81 ± 8.68 | 7.26 ± 7.84 | 0.310 |
| Fatty Liver Index (FLI) | 66.3 ± 26.5 | 67.4 ± 27.5 | 0.805 |
Subjects of cohort III were divided in two groups dependent on the serum WISP-1/CCN4 level – over and under detection limit (15 pg/ml). Data are mean ± S.D.; n.a. = not available