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AS-48 activity on HAT and nagana-causing T. brucei subspecies. The results are the mean ± SD of three independent experiments performed in triplicate. EC50: 50% inhibitory concentration of AS-48.
| EC50 (nM) | ||||
|---|---|---|---|---|
| BSF |
PCF |
Human cells |
||
| T. brucei rhodesiense | T. brucei gambiense | T. brucei brucei | T. brucei brucei | MRC-5 |
| 1.7 ± 0.2 | 2.6 ± 0.1 | 3.1 ± 0.2 | 140.0 ± 57.0 | No growth inhibition at 12,500 |
