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. 2018 May 4;8(2):287–294. doi: 10.1016/j.ijpddr.2018.05.001

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© 2018 The Authors. Published by Elsevier Ltd on behalf of Australian Society for Parasitology.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Efficacy of Cry5B against N. americanus and A. ceylanicum. (A) Intoxication of N. americanus adults in vitro over time at a dose of 250 μg/mL Cry5B purified protein (n = 6/dose/repeat, average of 2 repeats). (B) N. americanus hookworm burdens in placebo (water control) versus Cry5B treatment. Here and in similar figures, each dot represents hookworm burden in an individual hamster; long horizontal bar represents the average and short horizontal bars represent standard error. (C) N. americanus fecal egg counts (EPG) before treatment and after treatment with placebo (water control) or Cry5B. Here and in similar figures, each bar represents the average of all hamsters; error bar represents standard error. (D) A. ceylanicum hookworm burdens in placebo (water control) versus Cry5B treatment. (E) A. ceylanicum fecal egg counts (EPG) before treatment and after treatment with placebo (water control) or Cry5B. The dose in vivo for B-E is 40 mg/kg Cry5B, delivered as SCL.