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Cry5B is efficacious in the absence of a Th2 immune response. (A) H. polygyrus bakeri worm burdens in placebo (SL control) versus Cry5B SCL treatment in STAT6−/− mice. (B) H. polygyrus bakeri fecal egg counts in placebo (SL control) versus Cry5B SCL treatment in STAT6−/− mice. The Cry5B dose is 2 × 40 mg/kg. For comparison, a single 100 mg/kg dose reduced H. polygyrus bakeri burdens 67% in immunocompetent mice (Hu et al., 2010a).
