Fig. 5.

Repeated dosing with Cry5B does not abrogate efficacy. (A) Schematic of repeated dosing experiment. (B) Hookworm burdens from hamsters infected with A. ceylanicum hookworms and treated with Cry5B SCL, SL (no Cry5B), or water control. “Pre-dose” refers to hamsters treated with SCL or SL two times prior to infection and subsequent “treatment dose.” All hamsters were given a treatment dose of water, Cry5B, or SL (no Cry5B) 18 days post-infection. (C) Same experiment as in B except purified Cry5B protein was used for “pre-doses” and “treatment doses.” The dose of Cry5B used in all “pre-doses” and “treatment doses” was 10 mg/kg.