Table 3.
Test characteristics of the tear function tests when used alone for diagnosis of dry eye disease or ocular GVHD by NIH and ICCGVHD criteria, n = 96 patients (worst eye)
| Single test | Dry eye disease (DED) | Ocular GVHD by ICCGVHD criteria | Ocular GVHD by NIH criteriaa | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Patients with DED (n = 52) /without DED (n = 44) | Sensitivity/specificity (%) | Negative/positive predictive value (%) | Patients with oGVHD (n = 23) / without oGVHD (n = 73) | Sensitivity/ specificity (%) | Negative/positive predictive value (%) | Patients with oGVHD (n = 42) /without oGVHD (n = 51) | Sensitivity/specificity (%) | Negative/positive predictive value (%) | |
| Schirmer’s test, ≤ 5 mm | 39a/8 | 80/82 | 78/83 | 19a/20 | 86/72 | 94/49 | 34a,b/0b | 81/100 | 86/ 100 |
| Tear break-up time, ≤ 5 seconds | 35/9 | 67/80 | 67/80 | 12/29 | 55/60 | 81/29 | 27/15 | 64/71 | 71/ 64 |
| Ocular Surface Disease Index, ≥ 13 | 23/1 | 44/98 | 60/96 | 15/9 | 65/88 | 89/63 | 13/9 | 31/82 | 59 /59 |
| Corneal staining, ≥ grade 1 | 28/4 | 54/91 | 63/88 | 19/14 | 83/81 | 94/58 | 26/5 | 62/90 | 74 /84 |
| Conjunctival inflammation, ≥ grade 1 | 4/0 | 8/100 | 48/100 | 4/0 | 17/100 | 79/100 | 3/0 | 7/100 | 57/ 100 |
| Tear film osmolarity, > 308 mOsmol/l | 32c/27 | 62/39 | 53/54 | 10c/35 | 45/52 | 84/22 | 28c/30 | 67/41 | 68/ 48 |
cGVHD chronic graft-vs-host disease, DED dry eye disease, ICCGVHD International Chronic Ocular Graft-vs-Host-Disease Consensus Group, NIH National Institutes of Health, oGVHD ocular graft-vs-host disease
aSchirmer’s test not possible in three patients (pain)
bMean Schirmer of both eyes
cTear film osmolarity missing in five patients (technical problem/patient lacking tear film)