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. 2018 Jul 10;8:10406. doi: 10.1038/s41598-018-28751-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Gating of Kcv_NTS. (a,b) Typical time series of current measured in symmetrical KCl solutions of (a) 100 mM and (b) 1500 mM. Closed “C” and apparent open level “A” are labelled. (c) Representative amplitude histograms in 100 (black) and 1500 mM KCl (grey), recorded at −120 mV. (d) Markov model of gating comprising one open state O, and three closed states (S = slow, M = medium, F = fast). The labels in (a) correspond to the states in (d).