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. 2018 Jul 10;8:10410. doi: 10.1038/s41598-018-28506-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Induction of RUNX1 leads to increased BRD4 and histone acetylation at distal RUNX1 binding sites. (A) Schematic diagram depicting the in vitro differentiation system used in this study. FLK1+ haemangioblast cells were isolated from EBs and grown in blast culture media containing VEGF and IL-6 for 2 days. FLK1 expressing HE cells were then purified and cells were grown in HE media and treated with the indicated conditions for 18 hrs. (B) Average profiles of RUNX1 (Top panel), BRD4 (Middle panel) and H4K5Ac (Bottom panel) ChIP-seq peak enrichment centred on RUNX1 peaks (+/−1000 bp from peak centre). Enrichment at distal (left panels) and proximal (right panels) RUNX1 binding sites are shown.