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. 2018 Jul 10;8:10410. doi: 10.1038/s41598-018-28506-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Model depicting RUNX1 mediated recruitment of the pTEFb complex and LDB1 resulting in the onset of gene expression at RUNX1 target genes. Following induction of RUNX1 expression by Dox treatment, FLI1 and BRD4 move closer to RUNX1 sites which is associated with increased histone acetylation, CDK9 and LDB1 binding and activation of expression of haematopoietic genes.