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. 2018 Jul 10;9(7):772. doi: 10.1038/s41419-018-0813-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Global view of the ceRNA network. This network consists of 96 DElncRNAs, 50 DEmiRNAs, and 125 DEmRNAs. b Subnetworks of miR-223-5p, miR-378b, and miR-323b-3p. In Fig. 4a, b, rectangles, diamonds, and ellipses represented DEmiRNAs, DElncRNAs, and DEmRNAs between primary OS and normal controls, respectively. Red and green color represented upregulation and downregulation in primary OS compared to normal controls. c The functional enrichment map of GO terms. d Significantly enriched KEGG pathway of mRNAs in the ceRNA network