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. 2018 Jul 10;8:10403. doi: 10.1038/s41598-018-28427-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HIF-1α inhibition abolishes the up-regulation of COXIV-1 after microwave exposure and impairs mitochondrial functions in neuron-like cells. Neuron-like cells were treated with 400 μM Bisphenol A at 1 h before microwave exposure. At 9 h after exposure, cells were collected. The protein expression of HIF-1α, COXIV-1 and COXIV-2 were detected by western-blotting (A). And, the quantitative analysis were presented in (B), (C) and (D), respectively. The ratio of COXIV-1 to COXIV-2 was also calculated (E). To evaluate the mitochondrial functions, the ATP content (F), the mitochondrial membrane potentials (MMP) (G), and mitochondrial ROS (H) was analyzed by commercial kit. Data were shown as mean ± s.e.m. *p < 0.05, **p < 0.01, ***p < 0.001 compared to corresponding group.