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. 2018 Jul 10;8:10412. doi: 10.1038/s41598-018-28725-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Frequency and IEI of quantal GABAergic mIPSCs. (A) Raster plots displaying all events in 1 min from all patched cells. (B) Representative traces of spontaneous mIPSCs with detected events marked (*) for Wistar (blue) and WAR (fucsia) cells. (C) Histogram showing distribution of events by IEI recorded for 5 minutes (Bins of 200 ms). (D) Cumulative fraction of IEI per group. (Bins of 50 ms). (E) Mean global frequency of mIPSCs. (F) Histogram showing distribution of events by amplitude recorded for 5 minutes (Bins of 20 pA). (G) Cumulative fraction of amplitudes per group. (H) Mean amplitudes. N = 13 cells from 7 Wistars and N = 18 from 7 WARs.