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. 2018 Jul 10;8:10383. doi: 10.1038/s41598-018-28193-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Survival curves of patients with different clinicopathological characteristics. (A) Overall survival of all patients. (B) Poor differentiation predicted worse prognosis (P < 0.0001). (C) The pT classification in the 7^th edition failed to stratify by prognosis (P = 0.054). (D) The pT classification in the 8^th edition successfully stratified by prognosis (P = 0.033). (E) The pN classification in the 7^th edition stratified by prognosis (P < 0.0001). (F) The survival of patients classified as pN1 and pN2 in the 8^th edition was not significantly different (P > 0.05). (G) The OS was worse for patients with elevated CA19-9 than for those with decreased or normal CA19-9 (P = 0.001). (H) The OS of patients with elevated CA242 was worse than that of the other patients (P = 0.044).