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. 2018 Jul 4;9:1539. doi: 10.3389/fimmu.2018.01539

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Copyright © 2018 Gehring, Seeholzer and Krappmann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Positive and negative regulations of BCL10. Positive and negative regulating post-translational modification sites (phosphorylation and ubiquitination) and MALT1 cleavage site are depicted. Upper box highlighted in green shows modifications of BCL10 associate with positive impact on T cell activation. The red lower box summarizes negative regulatory effects that impinge on BCL10. Abbreviations: CARD, caspase-recruitment domain; S/T-rich, serine/threonine-rich region; BCL10, B-cell lymphoma/leukemia 10; MALT, mucosa-associated lymphoid tissue.