Figure 8.

(A) Normalized cophenetic correlation coefficient of the collective dissemination-associated gene network for tumor samples from 107 breast cancer patients who did not exhibit breast cancer relapse during the follow-up period and for tumor samples from 179 patients who exhibited metastatic relapse during the follow-up period. Gene expression data from the study by Wang et al. (53). (B) Normalized CCC of the Inflammatory breast cancer-associated gene network for the same patient groups as in (A). (C) Normalized CCC of the collective dissemination-associated gene network for tumor samples from 527 breast cancer patients with no metastasis during the follow-up period and for tumor samples from 13 patients with breast cancer metastasis during the follow-up period. Gene expression data from the cancer genome atlas (TCGA) (60). (D) Normalized CCC of the IBC-associated gene network for the same patient groups as in (C). Error bars indicate the SE in the estimate of CCC_norm calculated using the bootstrap method. *p-value < 0.05 and **p-value < 0.01.