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. 2018 Jul 4;8:244. doi: 10.3389/fonc.2018.00244

Figure 9.

Figure 9

(A–F) Gene set enrichment analysis using collective dissemination-associated genes (A,D), inflammatory breast cancer (IBC)-associated genes (B–E), and canonical epithelial-to-mesenchymal transition driving transcription factors (C–F) on: (A–C) gene expression data for epithelial and mesenchymal cell lines from the study by Grosse-Wilde et al. (39) and on (D–F) gene expression data for tumor samples from IBC and non-IBC breast cancer patients from the study by Iwamoto et al. (45). In (A–C), genes are ordered from left to right in decreasing order of correlation of expression with the epithelial phenotype. In (D–F), genes are ordered from left to right in decreasing order of correlation of expression with the IBC phenotype. Black bars along the top of each plot indicate the positions of hits to the gene set along the ordered list of genes. Nominal p-values of enrichment are indicated at the bottom of each plot. (G–I) Mean expression of CDH1 (E-cadherin) gene in tumor samples from IBC and non-IBC breast cancer patients in studies by (G) Iwamoto et al. (45), (H) Boersma et al. (46), and (I) Woodward et al. (24).