Table 3.
Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways identified to be significantly up-regulated from EE using Database for Annotation, Visualization, and Integrated Discovery (DAVID) software.
| Category | Term | Count | % | P-value | Genes |
|---|---|---|---|---|---|
| KEGG_PATHWAY | Metabolic pathways | 16 | 37.20930233 | <0.0001 | GUSB, UGDH, DPYS, CYP1A2, TST, CRYL1, GALM, CBR2, AKR1A1, ADH1, CYP2A5, PON1, HSD17B6, UGT2A1, CES1D, ALDH1A7 |
| KEGG_PATHWAY | Metabolism of xenobiotics by cytochrome P450 | 8 | 18.60465116 | <0.0001 | GSTM2, GSTA3, CBR2, CYP2F2, ADH1, EPHX1, UGT2A1, CYP1A2 |
| KEGG_PATHWAY | Drug metabolism—cytochrome P450 | 7 | 16.27906977 | <0.0001 | GSTM2, FMO5, GSTA3, FMO6, ADH1, UGT2A1, CYP1A2 |
| KEGG_PATHWAY | Pentose and glucuronate interconversions | 5 | 11.62790698 | <0.0001 | CRYL1, AKR1A1, GUSB, UGDH, UGT2A1 |
| KEGG_PATHWAY | Retinol metabolism | 6 | 13.95348837 | <0.0001 | ADH1, CYP2A5, HSD17B6, UGT2A1, ALDH1A7, CYP1A2 |
| KEGG_PATHWAY | Drug metabolism—other enzymes | 4 | 9.302325581 | 0.0007 | GUSB, DPYS, UGT2A1, CES1D |
| KEGG_PATHWAY | Glutathione metabolism | 3 | 6.976744186 | 0.0156 | GSTM2, GSTA3, GPX6 |
| KEGG_PATHWAY | Glycolysis / Gluconeogenesis | 3 | 6.976744186 | 0.0220 | GALM, AKR1A1, ADH1 |
| KEGG_PATHWAY | Steroid hormone biosynthesis | 3 | 6.976744186 | 0.0367 | HSD17B6, UGT2A1, CYP1A2 |
| KEGG_PATHWAY | Ascorbate and aldarate metabolism | 2 | 4.651162791 | 0.0904 | UGDH, UGT2A1 |