Table 4.
Linear regression analysis of xenobiotic metabolism-related genes for predicting glutathione activity.
| Factor | Oxidized Glutathione | GSH/GSSG | ||||||
|---|---|---|---|---|---|---|---|---|
| Model | Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | ||||
| Genes | Coefficient (SE) | p-value | Coefficient (SE) | p-value | Coefficient (SE) | p-value | Coefficient (SE) | p-value |
| GSTM2 | −1.526 (0.505) | 0.008* | – | – | 32.762 (9.241) | 0.003* | 22.895 | 0.024* |
| GSTA3 | −0.881 (0.346) | 0.022* | – | – | 19.249 (6.399) | 0.008* | – | – |
| CYP2A5 | −0.587 (0.176) | 0.004* | – | – | 9.231 (3.837) | 0.029* | – | – |
| ALDH1A7 | −0.432 (0.145) | 0.009* | – | – | 8.993 (2.719) | 0.004* | – | – |
| UGT2A1 | −0.307 (0.083) | 0.002* | −0.307 | 0.002* | 5.768 (1.678) | 0.003* | 3.916 | 0.029* |
| CRYL1 | −1.863 (1.052) | 0.096 | NA | 42.259 (19.818) | 0.049* | – | – | |
| AKR1A1 | −1.333 (0.699) | 0.075 | 32.038 (12.823) | 0.024* | – | – | ||
| DPYS | −0.517 (0.267) | 0.071 | 12.925 (4.817) | 0.016* | – | – | ||
| PON1 | −0.111 (0.214) | 0.611 | 5.318 (3.994) | 0.202 | NA | |||
*
p < 0.05; SE, standard error; NA, not associated. Linear regression analysis was conducted to identify significantly xenobiotic metabolism-related genes affecting oxidized glutathione (OG) and the ratio of reduced glutathione (GSH) to oxidized glutathione (GSSG) in olfactory bulb of mouse brain. The stepwise multiple linear regressions included UGT2A1 and GSTM2 in the final models.