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. 2018 Jul 4;9:490. doi: 10.3389/fneur.2018.00490

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Copyright © 2018 DeDominicis, Hwang, Cartagena, Shear and Boutté.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A cartoon timeline of protein based biomarkers following PBBI. Changes in protein biomarker levels are presented here for (A) tissue proteins and (B) CSF proteins as indicated, with increasing time on the x-axis and increasing protein abundance on the y-axis. Please note that axes are not drawn to scale and that these curves have been approximated from PBBI rats, with tissue curves representing changes in the brain regions of the immediate injury trajectory (frontal cortex and striatum).