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. 2018 Jul 4;9:1356. doi: 10.3389/fimmu.2018.01356

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Copyright © 2018 Zhao, Liao, Li, Zhang, Zheng, Zhou, Han, Dong and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Skin priming after kidney transplant does not promote donor-specific antibody (DSA) generation strongly. C57BL/6 donor skin grafts were transplanted into Balb/c recipient mice on day 7 after the Balb/c mice received kidney grafts from C57BL/6 mice (skin Tx group). Balb/c mice that received C57BL/6 donor kidneys without subsequent skin grafting acted as controls (nonskin Tx group). (A) Donor-matched skin grafts after kidney transplantation decreased the renal graft survival time but not strongly within 60 days. (B) Recipient serum DSA levels were detected by flow cytometry and expressed as mean fluorescence intensity (MFI). The DSA data present the mean ± SD of at least six independent samples. Donor-matched skin grafts after kidney transplantation accelerated DSA generation but not strongly within 30 days. (C) Sections of kidney grafts after transplantation were stained with hematoxylin and eosin (H&E) and periodic acid-Schiff (PAS), ×400; and for the deposition of IgG and C3d, ×200. Histological features of interstitial inflammation and tubulitis (arrows) in cell-mediated rejection and deposition of IgG and C3d in peritubular capillaries could be identified on day 21 (KT21) and 35 (KT35) post kidney transplantation in the skin Tx group. NS, no significant difference.