Table 3.
Summary of morphological findings in renal allografts.
| Groups | Animal# | pod |
Histology |
Overall histological interpretation | ||||||
| i score | t score | v score | g score | ptc score | c3d staining | IgG staining | ||||
| C3H-Balb/c, nonprimed | 1 | 5 | 3 | 0 | 0 | 0 | 0 | 0 | Minimal | IgG staining without evidence of rejection |
| 2 | 5 | 3 | 0 | 0 | 0 | 0 | 1 | Minimal | IgG staining without evidence of rejection | |
| 3 | 5 | 1 | 0 | 0 | 0 | 0 | 0 | Negative | Nonspecific changes | |
| 4 | 5 | 3 | 0 | 0 | 0 | 0 | 0 | Negative | Nonspecific changes | |
| C3H-Balb/c, primed-3d | 5 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | Negative | Nonspecific changes |
| 6 | 3 | 0 | 0 | 0 | 0 | 1 | 0 | Minimal | IgG staining without evidence of rejection | |
| 7 | 5 | 1 | 0 | 0 | 0 | 2 | 2 | Minimal | Active AMR | |
| 8 | 8 | 3 | 1 | 0 | 0 | 0 | 1 | Focal | CMR (borderline changes) mixed with active AMR | |
| 9 | 13 | 2 | 1 | 0 | 1 | 1 | 3 | Focal | Active AMR mixed with CMR (borderline changes) | |
| C3H-Balb/c, primed-4d | 10 | 3 | 0 | 1 | 0 | 0 | 2 | 2 | Minimal | Active AMR mixed with CMR (borderline changes) |
| 11 | 5 | 1 | 0 | 0 | 1 | 2 | 2 | Minimal | Active AMR | |
| 12 | 5 | 1 | 0 | 0 | 1 | 3 | 3 | Minimal | Active AMR | |
| 13 | 7 | 1 | 1 | 0 | 1 | 3 | 1 | Focal | Active AMR mixed with CMR (borderline changes) | |
| 14 | 8 | 0 | 0 | 0 | 1 | 3 | 2 | Focal | Active AMR | |
| C3H-Balb/c, primed-7d | 15 | 3 | 0 | 0 | 0 | 2 | 1 | 2 | Minimal | Active AMR |
| 16 | 6 | 1 | 0 | 0 | 2 | 2 | 3 | Focal | Active AMR | |
| 17 | 6 | 1 | 0 | 0 | 1 | 1 | 2 | Minimal | Active AMR | |
| 18 | 5 | 0 | 1 | 0 | 3 | 1 | 3 | Diffuse | Diffuse ATN | |
| 19 | 5 | 1 | 1 | 0 | 2 | 3 | 3 | Diffuse | Active AMR | |
| 20 | 5 | 1 | 1 | 1 | 3 | 2 | 3 | Diffuse | Diffuse ATN | |
| C57BL/6-Balb/c, primed | 21 | 5 | 2 | 0 | 0 | 1 | 0 | 1 | Minimal | Active AMR |
| 22 | 15 | 2 | 0 | 0 | 3 | 0 | 2 | Focal | Active AMR | |
| C57BL/6-Balb/c, skin Tx | 23 | 21 | 1 | 1 | 0 | 1 | 0 | 1 | Minimal | CMR (borderline change) mixed with active AMR |
| 24 | 35 | 3 | 2 | 0 | 1 | 0 | 2 | Focal | CMR IA mixed with active AMR | |
| 25 | 35 | 3 | 2 | 0 | 0 | 1 | 2 | Focal | CMR IA mixed with active AMR | |
Histological changes were evaluated based on the Banff 2015 lesion grading system and classification categories: 0, absent; 1, mild; 2, moderate; 3, prominent.
pod, days after kidney transplantation; Tx, transplantation; ATN, acute tubular necrosis; AMR, antibody-mediated rejection; CMR, cell-mediated rejection.