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. 2018 Jul 6;2(13):1585–1594. doi: 10.1182/bloodadvances.2017011643

Figure 6.

Figure 6.

Influence of SNV on VWF expression and half-life in a murine model. (A) Alignment of VWF amino acids p.789-795 across species. (B) Alignment of VWF nucleotides c.2365-2385 between human and mouse. (C) Expression of murine c.[2365G>A;2367T>C], c.2385C>T and c.[2365G>A;2367T>C;2385C>T] in vivo. **P < .0001. (D) Expression of wild-type and c.[2365G>A;2367T>C;2385C>T] murine VWF 4 weeks posthydrodynamic injection. (E) Half-life of plasma-derived murine VWF in VWF knockout mice. (F) Stabilization of endogenous FVIII:C in VWF knockout mice.