Table 2.
Histone demethylases with reported functions in lung cancer.
| Name | Target | Links to lung cancer |
|---|---|---|
| KDM1A,LSD1 | H3K4me2/me1, H3K9me2/me1 | Overexpressed in lung cancer [97, 98] |
| KDM2A | H3K36me2/me1 | Overexpressed in NSCLC [105] |
| KDM3A | H3K9me2/me1 | Overexpressed in NSCLC [108] |
| KDM4A | H3K9me3/me2,H3K36me3/me2 | Overexpressed in lung cancer [115] |
| KDM4C | H3K9me3/me2,H3K36me3/me2 | Overexpressed in lung sarcomatoid carcinoma [188] |
| KDM4D | H3K9me3/me2/me1,H3K36me3/me2 | Overexpressed in lung cancer [115] |
| KDM5A | H3K4me3/me2 | Overexpressed in lung cancer [117] |
| KDM6A | H3K27me3/me2/me1 | Loss led to lung tumorigenesis [123] |
| JMJD6 | Arginine on H3 and H4 | Overexpressed in lung cancer [137] |
| PAD4 | Arginine on H3 and H4 | Overexpression led to gefitinib resistance in NSCLC [143] |