Figure 5.

Interaction of the Tethered EphA2 Kinase Domain with a PIP₂-Containing Membrane

(A) Position and orientation of the tethered wild-type kinase domain (derived from data acquired across the three simulations; see Table 1 for details) displayed as a normalized density map showing the domain-bilayer centers-of-mass separation d and zz components of the rotation matrix R_zz. The main modes of interaction of the kinase with the bilayer is highlighted via a red box.

(B) Examples of the main mode (mode 1) of interaction of the tethered kinase domain with the membrane. See also Figure S4 for comparable analysis of the in silico mutant simulations.