Figure 8.

Integrative Model of the EphA2 Receptor at the Membrane

(A) Unliganded EphA2 dimer with the two ectodomains (shown in green and orange) on the extracellular surface the membrane, such that the two TM domains are apart and the center of mass distance between the two kinases is ca. 6 nm.

(B) Liganded conformation of the EphA2 dimer for which the center of mass distance between the two kinases is ca. 10 nm.

(C) An illustrative example of a higher order receptor cluster the formation of which is triggered by ligand binding. The ectodomain array was derived from (Seiradake et al., 2013), the position of the FN2 at the membrane surface by combined MD simulations and biophysical assays (Chavent et al., 2016), and the position of the kinase domain was extracted from CG simulations for mode 1 (see Figure 3).