Table 2.
Characteristics of people with diagnosis of hypertension, candidates for treatment, and candidates recommended treatment intensification in China based on 2014 evidence based guidelines for management of high blood pressure in adults developed by eighth Joint National Committee (JNC-8) and 2017 ACC/AHA hypertension guidelines. Values are percentages (95% CI) unless stated otherwise
| Characteristics |
Diagnosis of hypertension | Candidates for treatment | Candidates recommended treatment intensification | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| JNC-8 | ACC/AHA minus JNC-8 | P value* | JNC-8 | ACC/AHA minus JNC-8 | P value* | JNC-8 | ACC/AHA minus JNC-8 | P value* | |||
| No of people with hypertension, million | 184.2 (171.6 to 196.8) | 82.7 (76.1 to 89.3) | - | 74.5 (64.1 to 84.8) | 55.3 (50.9 to 59.6) | <0.01 | 35.7 (32.7 to 38.8) | 30.0 (24.3 to 35.7) | - | ||
| Demographics | |||||||||||
| Mean (95% CI) age, years | 59 (46 to 74) | 57 (46 to 74) | <0.01 | 57 (45 to 74) | 65 (48 to 75) | <0.01 | 59 (46 to 74) | 61.5 (46 to 75) | 0.06 | ||
| Sex: | <0.01 |
<0.01 |
0.32 |
||||||||
| Men | 46.3 (43.1 to 49.6) | 55.1 (51.8 to 58.3) | 46.4 (39.6 to 53.3) | 57.8 (54.2 to 61.3) | 47.1 (42.9 to 51.4) | 41.9 (32.5 to 51.8) | |||||
| Women | 53.7 (50.4 to 56.9) | 44.9 (41.7 to 48.2) | 53.6 (46.7 to 60.4) | 42.2 (38.7 to 45.8) | 52.9 (48.6 to 57.1) | 58.1 (48.2 to 67.5) | |||||
| Comorbidities | |||||||||||
| Diabetes | 17.4 (14.4 to 20.7) | 11.2 (7.9 to 15.2) | 0.01 | 15 (8.9 to 23.1) | 16.7 (12 to 22.3) | 0.68 | 28.2 (24 to 32.8) | 12.3 (9.4 to 15.7) | <0.01 | ||
| Smoking | 27.6 (24.9 to 30.5) | 33.3 (29.8 to 36.9) | 0.01 | 31.6 (25.8 to 37.8) | 37 (33.4 to 40.7) | 0.12 | 26.4 (22.4 to 30.6) | 18.4 (14.2 to 23.1) | 0.01 | ||
| Chronic kidney disease | 4.6 (3.7 to 5.6) | 1.8 (0.9 to 3.2) | <0.01 | 3.8 (2.7 to 5.2) | 2.8 (1.4 to 4.9) | 0.34 | 8.2 (6 to 10.8) | 3.7 (1.7 to 7) | 0.02 | ||
| ASCVD (MI, CHD, angina, stroke) | 19.4 (17.4 to 21.5) | 9 (7.5 to 10.7) | <0.01 | 9.4 (7.1 to 12.1) | 18.3 (15.6 to 21.3) | <0.01 | 29 (25.3 to 33) | 27.7 (21.6 to 34.6) | 0.73 | ||
| Mean (95% CI) 10 year ASCVD risk, % | 14.4 (1.3 to 43.7) | 8.5 (0.7 to 25.5) | <0.01 | 12.6 (1.2 to 42.1) | 14.9 (2.2 to 30.0) | <0.01 | 19.1 (1.8 to 51.8) | 13.6 (1.1 to 36.9) | <0.01 | ||
| Mean (95% CI) laboratory values | |||||||||||
| Glomerular filtration rate, mL/min/1.73 m2 | 89.5 (51.3 to 112.2) | 93.6 (61.9 to 116.2) | <0.01 | 91.8 (54.3 to 112.9) | 87.5 (59.3 to 110.9) | <0.01 | 87.7 (49.2 to 111) | 88.9 (52.8 to 114) | 0.27 | ||
| Total cholesterol, mg/dL | 197 (131 to 281) | 193 (129 to 282) | 0.03 | 196 (133 to 278) | 197 (128 to 288) | 0.87 | 198 (134 to 281) | 198 (126 to 300) | 0.91 | ||
| HDL cholesterol, mg/dL | 48 (24 to 83) | 50 (27 to 86) | <0.01 | 48.5(23 to 85) | 49.3 (25 to 86) | 0.44 | 46.5 (23.7 to 80.8) | 45.9 (25.5 to 73.1) | 0.56 | ||
| Treatment with antihypertensive agents, % | 46.8 (43.4 to 50.3) | 0 | <0.01 | 0 | 0 | to | 100 | 100 | - | ||
ACC=American College of Cardiology; AHA=American Heart Association; ASCVD=atherosclerotic cardiovascular disease; CHD=congestive heart disease; HDL=high density lipoprotein; MI=myocardial infarction.
Columns represent people meeting these criteria according to JNC-8, compared with those newly meeting these criteria under ACC/AHA guidelines (ACC/AHA minus JNC-8).
P value for comparison of characteristics in the “JNC-8” column and those in the “ACC/AHA minus JNC-8” column.