Table 1.
Baseline demographics and parameters for cohort. All values are mean (standard deviation) unless labelled otherwise.
| Cohort |
|||
|---|---|---|---|
| BASELINE PARAMETERS | Future non-dementia | Future dementia | |
| Drmographics | N | 97 | 22 |
| Average age (years) | 69.49 (9.54) | 73.20 (9.38) | |
| Male (%) | 60.82 | 77.27 | |
| Female (%) | 39.18 | 22.73 | |
| Rankin | 1.09 (0.99) | 1.59 (1.47) | |
| Diabetes (%) | 81.44 | 86.36 | |
| Non-Smoker (%) | 47.42 | 38.1 | |
| Ex-Smoker (%) | 34.02 | 42.85 | |
| Current Smoker (%) | 18.56 | 19.05 | |
| Treated Hypertension (%) | 92.78 | 90.91 | |
| Treated Hypercholesterolaemia (%) | 85.57 | 86.36 | |
| Average time to dementia onset (years) | – | 3.02 (1.49) | |
| Average age of dementia onset (years) | – | 76.23 | |
| MRI Parameters | Mean grey matter (mm3) | 681,213 (76616) | 670,374 (68616) |
| Mean white matter (mm3) | 333,930 (56698) | 320,761 (56010) | |
| Mean total cerebral volume (mm3) | 1,052,347 (114243) | 1,036,447 (109535) | |
| Mean lacunar volume (mm3) | 468 (671) | 646 (661) | |
| Mean white matter hyperintesities volume (mm3) | 37,204 (36937) | 45,312 (30469) | |
| SVDp: Percentage ratio of WMH to GM volumes (%) | 3.48 (3.01) | 4.34 (2.99) | |
| Cognitive | MMSE (Median and range)⁎⁎⁎ | 29 (22–30) | 26 (16–30) |
| NART⁎ | 100.03 (15.35) | 93 (14.96) | |
| Executive function⁎⁎ | −0.78 (1.07) | −1.35 (1.02) | |
| Processing speed | −0.83 (0.85) | −1.21 (0.95) | |
| Global functioning⁎ | −0.49 (0.83) | −0.90 (0.82) | |
| Working memory | −0.16 (0.94) | −0.30 (0.93) | |
| Long-term memory | 0.01 (0.98) | −0.44 (0.91) | |
Bonferroni corrected P < 0.003.
⁎
P < 0.05.
⁎⁎
P < 0.01.
⁎⁎⁎
P < .001.