Table 3.
Baseline demographic, MRI and cognitive parameters for the dementia subgroups defined using cluster ward-linkage.
| GROUP 1 | GROUP 2 | GROUP 3 | GROUP 4 | ||
|---|---|---|---|---|---|
| Demographics | N | 5 | 2 | 5 | 10 |
| Correctly predicted (%) | 0 | 0 | 80 | 70 | |
| Average age (years) | 65.02 (10.67) | 78.33 (9.90) | 75.93 (7.97) | 74.91 (7.23) | |
| Male (%) | 60 | 50 | 60 | 70 | |
| Female (%) | 40 | 50 | 40 | 30 | |
| Rankin | 1.20 (1.30) | 0.5 (0.71) | 2.4 (1.82) | 1.6 (1.43) | |
| MMSE | 27.40 (2.97) | 24.00 (4.24) | 22.80 (4.82) | 25.00 (3.13) | |
| NART | 100.00 (14.93) | 102.50 (33.23) | 92.20 (12.36) | 88.00 (12.53) | |
| Time to dementia onset (years) | 3.87 (1.43) | 2.82 (0.45) | 2.66 (0.77) | 2.83 (1.85) | |
| MRI Parameters | Mean grey matter (mm3) | 649,603 (84615) | 667,153 (18905) | 651,225 (73883) | 690,978 (84449) |
| Mean white matter (mm3) | 281,955 (79245) | 308,675 (34558) | 331,980 (37052) | 336,972 (52306) | |
| Mean total cerebral volume (mm3) | 1,002,964 (132771) | 1,022,045 (53432) | 1,043,029 (106885) | 1,052,777 (127415) | |
| Mean lacunar volume (mm3) | 1137.60 (948.89) | 5.50 (7.78) | 706.20 (707.45) | 499.00 (381.69) | |
| Mean white matter hyperintesities volume (mm3) | 71,406 (26707) | 46,218 (31.82) | 59,824 (38959) | 24,827 (14590) | |
| SVDp: Percentage ratio of WMH to GM volumes (%) | 7.27 (3.04) | 4.53 (0.24) | 5.27 (3.40) | 2.28 (1.16) | |
| Cognitive | Executive Function | −0.68 (1.04) | −1.87 (0.15) | −1.06 (1.30) | −1.73 (0.53) |
| Processing Speed | −0.43 (0.67) | −2.02a | −0.80 (1.24) | −1.72 (0.58) | |
| Global Functioning | −0.28 (0.69) | −1.24 (0.24) | −0.56 (1.14) | −1.31 (0.33) | |
| Working Memory | 0.00 (0.78) | −0.17 (1.18) | 0.27 (1.09) | −0.77 (0.75) | |
| Long-term Memory | −0.05 (1.10) | −0.42 (0.12) | −0.25 (1.26) | −0.74 (0.69) | |
a
Only one data point available, other subject unable to complete task due to unrelated disability.