Table 3.
Prevalence of single cells manifesting MLME phenotypes within populations of TERTneg and TERTpos cells of human and mouse embryos.
| Classification category | Number of cells, n | MLME phenotype, n | MLME, % | P value |
|---|---|---|---|---|
| Human embryo (n = 1529) | 1529 | 267 | 17.5 | |
| TERT negative (n = 710) | 710 | 92 | 13.0 | 4.2338E-06 |
| TERT positive (n = 819) | 819 | 175 | 21.4 | 4.2338E-06 |
| Top 3% TERTpos (n = 25) | 25 | 17 | 68.0 | 2.1534E-08 |
| Bottom 97% TERTpos (n = 794) | 794 | 158 | 19.9 | 0.00178042 |
| Top 5% TERTpos (n = 41) | 41 | 24 | 58.5 | 1.993E-09 |
| Bottom 95% TERTpos (n = 778) | 778 | 151 | 19.4 | 0.00671443 |
| Top 10% TERTpos (n = 82) | 82 | 36 | 43.9 | 5.9454E-09 |
| Bottom 90% TERTpos (n = 737) | 737 | 139 | 18.9 | 0.02051266 |
| Mouse embryo (n = 259) | 259 | 52 | 20.1 | |
| TERT negative (n = 178) | 178 | 32 | 18.0 | 0.06008626 |
| TERT positive (n = 81) | 81 | 20 | 24.7 | 0.06008626 |
| Top 9% TERTpos (n = 7) | 7 | 2 | 28.6 | 0.27984881 |
| Top 16% TERTpos (n = 13) | 13 | 3 | 23.1 | 0.25279801 |
The MLME phenotype was defined in individual human and mouse embryonic cells as described in the legend to the Table 2. The relative ranks of individual cells were defined by the 23-gene signature score. P values were estimated using the hypergeometric distribution test.