Table 1.

Metabolic parameters of young IGF-II/LDLR^–/–ApoB^100/100 mice on HFD.

		Control	A-285222
Glucose (mmol/L)
Fasted	Males	7.16 ± 0.99	8.92 ± 2.09*
	Females	6.77 ± 1.19	6.69 ± 0.93
Fed	Males	9.47 ± 3.14	9.17 ± 1.80
	Females	8.46 ± 1.79	7.96 ± 1.69
Insulin (µg/L)
	Males	0.549 ± 0.37	0.492 ± 0.37
	Females	0.383 ± 0.12	0.323 ± 0.18
Triglycerides (mmol/L)
	Males	2.39 ± 0.99	2.28 ± 1.35
	Females	1.55 ± 0.50	1.28 ± 0.62
Cholesterol (mmol/L)
	Males	33.9 ± 6.81	33.7 ± 9.00
	Females	34.8 ± 9.44	33.9 ± 7.43
OPN (ng/mL)
	Males	151 ± 37	135 ± 25
	Females	136 ± 23	122 ± 19
Body weight (g)
	Males	34.4 ± 2.7	33.1 ± 2.5
	Females	24.5 ± 3.3	24.7 ± 2.6

HFD: high-fat diet; OPN: osteopontin.

Values are expressed as mean ± SD (N = 8–11 mice/group from Study I and II) and represent values after overnight fasting measured at the end of the treatment (week 8 of study protocol). Blood glucose values under non-fasting conditions are also shown (measured during week 7 of study protocol).

^*p < 0.05 versus control. Two-way ANOVA for the effect of gender and treatment revealed significant effects of gender on plasma triglycerides (p = 0.0035) and body weight (p < 0.0001).