Table 1. Cells described as sources of IL-17 and/or IL-22.
| Cell | Cytokine | Further secreted factors | Surface markers |
|---|---|---|---|
| Th17 [45] | IL-17, IL-22 | IL-21, IL-26, TNF-α, (IL-10), CCL20 | CD4+ CCR4+ CCR6+CXCR3- CD161+ [46, 47] IL-23R+ |
| Th22 [8, 9] | IL-22 | TNF-α, (IL-10), FGFs | CD4+ CCR4+ CCR6+CCR10+ |
| NKT [48] | IL-17, IL-22 | IFN-g | CD3+ CD56+ |
| Lymphoid tissue-inducing cell [49] | (IL-17), IL-22 | TNF-α, lymphotoxin | CD3- CD56- NKp44- CD117+ CD127+ CD161+ |
| RORc+ NKp46+ cells | (IL-17), IL-22 | CD3- CD56+ NKp44+ NKp46+ NKG2D+ CD117+ CD127+ |
|
| NK22 [5] | IL-22 | TNF-α, lymphotoxin, IL-26 | CD3- CD56+ NKp44+ CD117+ CD127+ CD161+ |
| CD8+IL-17+ [50] | IL-17 | CD3+ CD8+ CD45RO+ | |
| gd T cell [51] | IL-17 | Mouse: CD3+ CD4- CD8- CD27- [52] CD25+ CD122- [53] |
|
| T follicular helper cell [6] | IL-17 | IL-21 | CD4+ ICOS+ CXCR5+ |
| Monocyte [54, 55] Macrophage [55] | IL-17 IL-22 |
CD11b+ CD68+ | |
| Neutrophil granulocyte [56] | IL-17 |