Table 1. Animal dander allergens that have been recognized by WHO/IUIS Allergen Nomenclature Sub-Committee (www.allergen.org).
| Allergen | MW (kDa) | IgE prevalence (%) | Cross-reactivity/species specifity | Protein family |
|---|---|---|---|---|
| Cat (Felis domesticus) | ||||
| Fel d 1 [44] | 18 | > 90 | Species-specific | Secretoglobin |
| Fel d 2 [52] | 69 | 14 – 30 | Marker for cross-sensitization to other mammalian albumins, responsible for cat-pork syndrome [29, 50, 58] | Serum albumin |
| Fel d 3 [33] | 11 | 10 | nd | Cystatin |
| Fel d 4 [56] | 22 | 63 | Cross-reactive with Can f 6 and Equ c 1; partially cross-reactive with Can f 2 [31, 40, 45] | Lipocalin |
| Fel d 5 [1] | 28, 64 | 38 | Cross-reactive with Fel d 6 | Immunoglobulin A |
| Fel d 6 [2] | 28, 94 | nd | Cross-reactive with Fel d 5 | Immunoglobulin M |
| Fel d 7 [57] | 18 | 37 | Probably cross-reactive with Can f 1 | Lipocalin |
| Fel d 8 [57] | 24 | 19 | nd | Latherin |
| Dog (Canis familiaris) | ||||
| Can f 1 [35] | 18 – 25 | 49 – 75 | Probably cross-reactive with Fel d 7, partially cross-reactive with Can f 2 and human tear lipocalin (TL) with unknown clinical relevance [53] | Lipocalin |
| Can f 2 [35] | 19 | 10 – 40 | Partially cross-reactivity with Can f 1, and Fel d 4 [53, 40] | Lipocalin |
| Can f 3 [47] | 69 | 16 – 30 | Cross-reactive with albumins from other mammals [58] | Serum albumin |
| Can f 4 [41] | 16 – 18 | 35 | Cross-reactive with Bos d 23k [41] | Lipocalin |
| Can f 5 [42] | 28 | 70 | Cross-reactive with human prostate-specific antigen (PSA) [6] | Kallikrein |
| Can f 6 [31, 45] | 27 – 29 | 38 – 61 | Cross-reactive with Fel d 4, Equ c 1 [34] | Lipocalin |
| Horse (Equus caballus) | ||||
| Equ c 1 [21] | 22 – 25 | 42 – 76 | Cross-reactive with Fel d 4, Can f 6, and Mus m 1 [34, 45, 53] | Lipocalin |
| Equ c 2 [8] | 16 | nd | nd | Lipocalin |
| Equ c 3 [9] | 65 – 67 | 18 | Cross-reactive with albumins from other mammals | Serum albumin |
| Equ c 4 [43] | 17 | 77 | nd | Latherin |
| Rabbit (Oryctolagus cuniculus) | ||||
| Ory c 1 [5] | 17 – 18 | nd | nd | Lipocalin |
| Ory c 2 [5]* | 21 | nd | nd | Lipocalin |
| Ory c 3 [27] | 19 – 21 | 77 | Species-specific | Secretoglobin |
| Ory c 4 [28] | 24 | 46 | Probably cross-reactive with Fel d 4, Can f 6, and Equ c 1 | Lipocalin |
| Guinea pig (Cavia porcellus) | ||||
| Cav p 1 [16] | 20 | 70 | nd | Lipocalin |
| Cav p 2 [32] | 17 | 65 | Species-specific | Lipocalin |
| Cav p 3 [32] | 18 | 54 | Species-specific | Lipocalin |
| Cav p 4 [32] | 66 | 52 | Cross-reactive with albumins from other mammals | Serum albumin |
| Cav p 6 | 18 | nd | Probably cross-reactive with Fel d 4, Can f 6, and Equ c 1 | Lipocalin |
| Golden hamster (Mesocricetus auratus) | ||||
| Mes a 1 [25] | 20.5, 24 | nd | Probably cross-reactive with European hamster | Lipocalin |
MW = molecular weight; nd = not determined; *name used in publications, but not officially recognized.