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. 2017 Aug 4;1(2):169–189. doi: 10.5414/ALX01617E

Table 4. Examples of successful clinical validation of molecular allergy diagnostic work-up (plant-based allergen sources).

Allergen source Allergens Comment Reference
Hazelnut rCor 1.04, rCor a 2, rCor a 8, nCor a 9, rCor a 11 Clinical evaluation of the component-specific diagnosis in patients with hazelnut allergy from various regions (Denmark, Switzerland, Spain); diagnosis partially supported by controlled oral provocation, additional cohorts with pollen allergy and non-atopics; heterogeneous sensitization profiles depending on the region investigated. [47]
Carrot rDau c 1.0104, rDau c 1.0201, rDau c 4, rDau c IFR 1, rDau c IFR 2, rDau c Cyc A) Clinical evaluation of 3 carrot allergens in patients whose carrot allergy had been confirmed by challenge testing compared to patients with birch pollen allergy without carrot allergy and non-atopic controls B) Clinical evaluation of the component-specific diagnosis in patients with hazelnut allergy from various regions (Denmark, Switzerland, Spain); diagnosis partially supported by controlled oral provocation, additional cohorts with pollen allergy and non-atopics; heterogeneous sensitization profiles depending on the region investigated. [48, 49]
Cherry rPru av 1, rPru av 3, rPru av 4 Clinical evaluation of component-specific diagnostic work-up in Central and South European (Spanish) patients with cherry allergy; diagnosis partially confirmed by controlled oral provocation, additional cohorts with pollen allergy and non-atopics; heterogeneous sensitization profiles depending on the region investigated and clear advantage of single allergens over extract-based diagnostic work-up (prick test; specific IgE with cherry extracts). [50]
Celery rApi g 1.01, rApi g 4, nApi g 5 Clinical evaluation of component-specific diagnostic work-up in patients with celery allergy; diagnosis confirmed by controlled oral provocation, additional cohorts with pollen allergy and non-atopics; clear advantage of single allergens over extract-based diagnostic work-up; nApi g 5-specific IgE is significantly directed against CCD. [51, 52]