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. 2017 Aug 4;1(2):169–189. doi: 10.5414/ALX01617E

Textbox 1. Results and consequences of molecular allergen cloning (cf [3]).

Allergen definition: allergen nomenclature based on sequence
Discovery of new allergens
- Hierarchy of allergens from a common source
- Identification and understanding of cross-reactivities
- Grouping of gene families of major allergens
- Allergens for identification of 3D structure
- Geographic variants in allergen sequences
- Sequences suitable for peptide immunotherapy
- Recombinant proteins for diagnosis and immunotherapy
- Recombinant proteins for studies using defined and reproducible reagents
- Sequences for peptides for investigation of T-cell responses
- Species-specific allergens for epidemiological studies
- Alteration of genes towards hypoallergens
- Alteration of genes for improvement of immunotherapy