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. 2018 Jul 11;16:192. doi: 10.1186/s12967-018-1554-z

Table 1.

Canonical loadings for the fatigue (criterion) and quality of life (predictor) in the Parkinson group

Variables Mean (SD) Range Loadings
Predictor variables (quality of life)
 1. PD Quality of Life Questionnaire Summary Index, PDQ-39SI 27 (20) 4–65 0.82
 2. Non-Motor Symptoms Questionnaire, NMS-Q 12 (6) 1–21 0.73
 3. Hospital Anxiety and Depression Scale, HADS 12 (7) 3–24 0.71
 4. Non-Motor Symptoms Scale, NMSS 66 (44) 5–190 0.67
 5. Unified Parkinson’s Disease Rating Scale Total, UPDRS 43 (14) 20–73 0.66
 6. Duration of disease (years) 8 (5) 1–22 0.46
 7. Epworth Sleepiness Scale, ESS 8 (4) 1–15 0.40
 8. Age at diagnosis (years) 63 (9) 45–79 0.38
 9. Body mass index, BMI 27 (7) 17–54 − 0.18
 10. Life orientation test, LOT-R 17 (5) 5–24 − 0.40
 11. Montreal Cognitive Assessment, MoCA 26 (4) 15–30 − 0.52
 12. PD sleep Scale 100 (26) 42–144 − 0.53
 13. EPIC Physical Activity Questionnaire, ePAQ 72 (68) 8–318 − 0.43
Criterion variables (Fatigue)
 1. Fatigue Severity Scale, FSS 38 (15) 11–60 0.86
 2. Functional Assessment of Chronic Illness Therapy Fatigue Scale, FACIT-F 32 (12) 14–50 − 0.83
 3. Parkinson Fatigue Scale, PFS 50 (17) 17–77 0.80
 4. Visual Analog Fatigue Scale, VAFS 6 (2) 2–10 − 0.69

All quality of life variables except body mass index reliably predicted perception of fatigue in Parkinson’s disease. The PDQ-39SI produced the strongest prediction