Table I.
Morphological signs of colonic damage observed 1 or 24 h after rectal administration of saline or acetic acid solution (colitis) in rats pretreated with saline or obestatin given at a dose of 4, 8 or 16 nmol/kg/dose (obestatin 4, obestatin 8 or obestatin 16)
| Variable | Morphological changes | ||||
| Grading of colonic damage (0–2) | Inflammatory infiltration (0–3) | Depth of damage (0–3) | Fibrosis (0–3) | ||
| 1 h: | |||||
| Saline (control) | 0 | 0 | 0 | 0 | |
| Obestatin 4 | 0 | 0 | 0 | 0 | |
| Obestatin 8 | 0 | 0 | 0 | 0 | |
| Obestatin 16 | 0 | 0 | 0 | 0 | |
| Saline + colitis | 2 | 2 | 2 | 1 | |
| Obestatin 4 + colitis | 1–2 | 2 | 2 | 1 | |
| Obestatin 8 + colitis | 1 | 1–2 | 1 | 1 | |
| Obestatin 16 + colitis | 1 | 1–2 | 1 | 1 | |
| 24 h: | |||||
| Saline (control) | 0 | 0 | 0 | 0 | |
| Obestatin 4 | 0 | 0 | 0 | 0 | |
| Obestatin 8 | 0 | 0 | 0 | 0 | |
| Obestatin 16 | 0 | 0 | 0 | 0 | |
| Saline + colitis | 2 | 3 | 2–3 | 2 | |
| Obestatin 4 + colitis | 1–2 | 2–3 | 2 | 1 | |
| Obestatin 8 + colitis | 1–2 | 2 | 1 | 1 | |
| Obestatin 16 + colitis | 1–2 | 2 | 1 | 1 | |
Numbers represent the predominant histological grading in each group.