Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Overexpression of miR-135b-5p promotes activation of the Nrf2/ARE signaling pathway. HT22 cells were transfected with ARE reporter vector and miR-135b-5p mimics or inhibitor for 24 h and then subjected to OGD/R treatment. A – Protein expression of Nrf2 was detected by Western blot analysis. B – ARE activity was detected by dual-luciferase reporter assays. The mRNA expression of HO-1 (C) and NQO1 (D) was detected by RT-qPCR
&p < 0.05 vs. control and *p < 0.05 vs. OGD/R + NC.
