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The effect of acute treatment with metformin (MET) on naloxone-precipitated morphine withdrawal sign (jumping). MET (5 and 50 mg/kg) was administered 45 min before the last dose of morphine (10 mg/kg twice a day, s.c) on day 7. Data are expressed as mean ± SEM of 6-8 rats. *** P < 0.001 vs. saline-treated group.
