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. 2018 Aug;13(4):360–367. doi: 10.4103/1735-5362.235163

Scheme 1.

Scheme 1

Synthesis pathway for the preparation of 4-aminoquinazoline derivatives. Reagents and conditions: (i) Formamide, micro wave; (ii) SOCl2, dimethylformamide (DMF), reflux, 20 h; (iii) Aniline derivatives, iPrOH/DMF, reflux, 20 h; (iv) NaH, ROH, DMF, reflux, 7 h.